Evidence-Informed Approach to De-Prescribing of Atypical Antipsychotics (AAP) in the Management of Behavioral Expressions (BE) in Advanced Neurocognitive Disorders (NCD) (77069)

Session Information:

Session: On Demand
Room: Virtual Video Presentation
Presentation Type: Virtual Presentation

All presentation times are UTC + 9 (Asia/Tokyo)

The LuBAIR™ Paradigm is a novel approach to ascribe meaning to behavioral expressions in advanced neurocognitive disorders when the reliability of a clinical assessment is limited. The meaning ascribed to each behavioral category was used to identify those which are likely to respond to the use of atypical antipsychotics, in their management. De-prescribing was attempted on patients who qualified to enter this retrospective study. De-prescribing was defined as successful if individuals were completely withdrawn from AAP and remained off them for 60 days, without the re-emergence of behaviors. The LuBAIR™ Inventory was filled on two occasions. The data collected on the second occasion, in the successful and failed de-prescribed groups, were compared in this retrospective study. MANOVA, Chi-Square paired t-test statistical analyses were used to detect the differences in the behavioral categories between the two cohorts. Cohen d was used to measure effect size. Patients who did not have Mis-Identification and Goal-Directed Expressions were more likely to successfully de-prescribe: X2 (1, N = 40) = 29.119 p < 0.0001 and X2 (1, N = 40) = 32.374, p < 0.0001, respectively. Alternatively, the same behavioral categories were more likely to be present in patients who failed de-prescribing: MANOVA and paired t-test (p < 0.0001). Atypical antipsychotics, in their role as an antipsychotic and mood stabilizer, may be used to manage Mis-Identification and Goal-Directed Expressions, respectively.

Atul Sunny Luthra, McMaster University, Canada
Raymond LinBin Gao, St. Peter’s Hospital, Canada
Shannon Remers, Homewood Health Inc., Canada
Peter Carducci, University of Waterloo, Canada
Joanna Sue, St. Peters Hospital, Canada

About the Presenter(s)
Dr Atul Sunny Luthra is a University Associate Professor/Senior Lecturer at McMaster University in Canada

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Posted by Clive Staples Lewis

Last updated: 2023-02-23 23:45:00